Course Outcomes-M.Sc Chemistry


PH1CO1 Organometallics and Nuclear chemistry
1.     To know and understand the different properties and structures for organometallic compounds from different parts of the periodic table and their trends.
2.     To know principal synthetic routes to various classes of organometallic compounds.
3.     To know and understand the reactivity of organometallic compounds including their application in synthesis.
4.     To know methods and examples for the study of organometallic compounds in the gas phase, solution phase and solid state.
5.     To know common ligand classes in organometallic chemistry, their effects on organometallic compounds, and influence on reactivity and catalysis.
6.     To know and understand key mechanistic steps in reactions involving organometallic compounds.
7.     Students will learn about synthetically useful transformations including oxidations, reductions, enolate reactions, percicyclic reactions, organometallic reactions, and reactions of electron deficient species. The emphasis will be on developing a mechanistic understanding of selectivity and synthetic strategy.
8.     The students will know the importance of nuclear chemistry and its applications.
9.     Students will measure the rate of nuclear decay of a short-lived isotope to determine a number of statistical and physical properties.
PH1CO2 Structural and Molecular Organic Chemistry
1.        Predict the major and minor products of a variety of organic reactions with appropriate stereochemistry and regiochemistry.
2.        Understand and reproduce accepted mechanisms of organic reactions including all intermediates, arrows, charges, and resonance structures.
3.        Understand and interpret spectra (IR, 1H NMR, 13C NMR, Mass Spec., and UV-VIS) of organic molecules.
4.        Name or draw the structure of an organic molecule using substitutive and/or functional class IUPAC nomenclature.
5.        Devise reasonable high-yield synthesis of a target molecule from given organic starting materials.
Understand physical properties of organic molecules.
6.        Perform a laboratory experiment using conventional equipment, instrumentation, and techniques and understand the principles well enough to interpret the data collected.
7.        Emphasis on aromatic and aliphatic substitution reactions, elimination reactions, and the chemistry of carbonyl compounds; application of spectroscopic methods to organic chemistry.
8.      Students will transition from memorization to understanding by programmed exposure to integrated problems involving mechanism, multi-step synthetic planning, and organic spectroscopy.
PH1CO3 Quantum chemistry and group theory
1.     Introduction to the postulates and general principles of quantum mechanics. Approximations based on variational method and time independent perturbation theory. Application to harmonic oscillator, rigid rotor, one-electron and many-electron atoms, and homo-and hetero-nuclear diatomic molecules
2.     Group theory. Application of quantum mechanics to polyatomic molecules and molecular spectroscopy. Intermolecular forces and the gas, liquid and solid states. Distributions, ensembles and partition functions. Transport properties.
PH1CO4 Classical and Statistical Thermodynamics
1.     Explain statistical physics and thermodynamics as logical consequences of the postulates of statistical mechanics;
2.     Apply the principles of statistical mechanics to selected problems;
3.     Apply techniques from statistical mechanics to a range of situations;
4.     Use the tools, methodologies, language and conventions of physics to test and communicate ideas and explanations.
5.     Use the tools, methodologies, language and conventions of physics to test and communicate ideas and explanation.
PH2CO5 Coordination chemistry
1.     Bonding and isomerism in coordination compounds, crystal field theory, and electronic properties of ligands. Covered also are metal bonding in clusters, the HSAB concept, chelate effect, and complex stability. Reactions of complexes are analyzed, and the role of transition metal compounds in catalysis is described with examples.
PH2CO6 Organic reaction mechanisms
1.     It provides an introduction to the synthesis of complex organic molecules. Transformations for C-X and C-C bond-formation, functional group reactivity, chemoselectivity, regioselectivity, and the strategy of multistep synthesis will be the core topics that are covered. Concepts include strategy/retrosynthesis, advanced aromatic chemistry, protecting groups, stereochemistry, enolates and other carbonyl chemistry, alkene synthesis, reduction/oxidation (introductory), heterocycles, cross-coupling reactions and other modern methods of synthesis. A central theme of this course is the ability to recognize retrosynthetic simplification of target molecules and be able to provide forward synthetic proposals. Although the logic for this type of analysis evolved around natural products, this course emphasizes parallel strategies as they are applied to complex drugs. Given the recent increase in the structural complexity of drug molecules required to achieve specificity and potency while eschewing metabolic liabilities, knowledge of synthetic strategy is increasingly important in the pharmaceutical industry.
2.     Understand the concept and definitions of aromaticity.
3.     Draw products and reaction mechanisms for many reactions including all aromatic compounds, carbonyl-containing compounds, amines, carbohydrates, amino acids, lipids.
4.     Recognize stereochemistry and be able to apply the Cahn-Ingold-Prelog system to designation of stereochemistry (E/Z, R/S, re/si).
5.     Apply stereochemical aspects to reaction mechanism.
6.     Understand the fundamentals of reaction kinetics and be able to apply to the determination of reaction mechanism.
7.     Employ the reactions learned in designing multistep organic synthesis.
PH2CO7 Chemical bonding and Computational chemistry
1.     By the end of this course, students: will have a conceptual understanding of the laws of quantum mechanics necessary for the description of atoms and molecules and their chemical reaction; will be able to choose the appropriate method (in terms of applicability, accuracy, and economy) for the calculation of a given chemical problem; will be able to perform, understand, and interpret the results of the calculations and bring them in a publication ready form.
PH2CO8 Molecular spectroscopy
1.     Modern theoretical and experimental methods used to study problems of molecular structure and bonding; emphasis on spectroscopic techniques.
2.     The student performs rigorous characterization of their compound using 1- and 2-dimensional NMR techniques (1 H and 13C), mass spectrometry, infrared spectroscopy and polarimetry. The students then turn to analysis of the compound as a potential pharmaceutical by measuring the lipophilicity (logP) using liquid chromatography/mass spectrometry, binding to human serum albumin using fluorescence and circular dichroism spectroscopy, and toxicity using a brine shrimp assay. Though-out the course the students are grouped in a “team” that has related compounds and are asked to compare and contrast their data from these various experiments to enhance data analysis skills required for professional chemists. There is a weekly lecture component to provide the background for each element of the laboratory course.
PH3CO9 Synthetic and bioorganic chemistry
1.     A central theme of this course is to recognize the chemical building blocks in nature that enable student to link structures to biosynthetic hypotheses. The four major biosynthetic pathways (fatty acid/poly propionate synthesis, shikimate pathway, isoprenoids and alkaloid biosynthesis) are consistently discussed in detail. Additional topics can include biosynthetic origins of carbohydrates and nonribosomal peptides (NRPs), structure determination by multiple spectroscopic methods (MS and NMR), and the chemical synthesis of natural products and their derivatives.
PH3C10 Physical Chemistry
2.     Students will acquire a good knowledge on the chemical kinetics, unimolecular and bimolecular reactions, fast reactions, Catalysis, Surface chemical reactions and Photochemistry of atoms and molecules.
3.     An introduction to the chemistry, preparation, structure and physical properties of inorganic nanoparticles. Students will learn about methods to synthesize inorganic nanoparticles, and learn to evaluate particle size and shape distributions. At the end of the class, they will be able to predict the stability of nanoparticles in solution, and to understand the nucleation and growth of nanoparticles. They will know how to analyze the size-dependent physical properties of nanoparticles, and they will know about the different techniques (electron microscopy, X-ray diffraction) to study nanoparticles. Students will also be aware of applications of nanoparticles in science and technology. It is expected that students enrolled in this class have a basic understanding of physical chemistry.
PH3C11 Drug design and pharmacology
1.     This class provides an introduction to the chemical principles behind the design and production of pharmaceutical agents. Focus is on explaining and predicting how small organic molecules bind to biological receptors, inhibit enzymes and get metabolized. This course draws on and expands upon material covered in introductory organic chemistry such as proposing reasonable arrow-pushing mechanisms for organic reactions and predicting the reactivity of organic molecules with particular reagents.
2.     Demonstrate an understanding of the chemical role antibiotics play in the biology of cells
3.     Demonstrate by example the fundamental rules behind atoms that leads to the formation of chemical bonds, organic functional groups, and water solubility of carbon based molecules.
4.     Demonstrate an ability to design, implement, and evaluate the results of experimentation using standard scientific methodologies such as hypothesis formulation and testing.
5.     Demonstrate an ability to interpret information presented in scientific literature.
6.     Demonstrate an appreciation of research science and its role in solving a human health issue-the antibiotic crisis.
7.     Clearly communicate research results via oral, written and visual formats.
PH3C12 Spectroscopic methods in Chemistry
1.     To develop expertise relevant to the professional practice of chemistry.
2.     To develop an understanding of the range and theories of instrumental methods available in analytical chemistry.
3.     To develop knowledge pertaining to the appropriate selection of instruments for the successful analysis of complex mixtures.
4.     To develop an understanding of the role of the chemist in measurement and problem solving in chemical analysis.
5.     To provide an understanding of and skills in advanced methods of separation and analysis.
6.     To provide practical experience in selected instrumental methods of analysis
7.     To extend skills in procedures and instrumental methods applied in analytical tasks.
8.     To expand skills in the scientific method of planning, developing, conducting, reviewing and reporting experiments.
9.     To extend understanding of the professional and safety responsibilities residing in working on environmental problems.
PH4EO1 Bacteriology and biochemistry
1.     Students will learn about normal and abnormal cellular growth and mitosis control pathways, and the chemical mechanism of action of selected chemotherapeutic agents.
PH4EO2 Advanced pharmaceutical operations ans dispensing
1.     Through lectures from outside speakers with careers in the Pharmaceutical/Biotech industry, this course demonstrates real-life applications of the fundamental principles taught in 130A. Broader societal issues such as ethical aspects of scientific research that has clear implications to public health will be explored. Through molecular modelling laboratory experiments, students learn the process of rational drug design.
PH4EO3 Medicinal chemistry
1.     To recognize the importance of inorganic molecules in supporting organic biological systems. 
2.     To learn about how metal ions function as catalytic and structural centers in biological systems. 
3.     To learn about the metal ion transport and storage within cells and how any malfunction can result in various diseases. 
4.     To gain insight into cutting edge developments that utilizes metal ions for medical purposes.
5.     To learn methods, including spectroscopy techniques, used to study metal ions in biological systems. 
6.     To develop the skill to critically read primary literature, and to interpret experimental observations. 
7.     To develop an appreciation for the structure and function of metal ions in the biological systems and how chemists aim to mimic them.
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